Kisspeptin-10

Description

Kisspeptin-10 (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe) is a biologically active fragment of the Kisspeptin protein that plays a central role in regulating reproductive hormone secretion. By stimulating the hypothalamic release of gonadotropin-releasing hormone (GnRH), it increases downstream secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), supporting follicular development, ovulation, and egg quality.

Mechanism of Action

• Stimulates GnRH release from the hypothalamus

• Increases LH and FSH secretion, promoting follicle maturation and ovulation

• Supports follicular development in natural cycles and ART (assisted reproductive technology) protocols

• Can replace hCG for triggering ovulation in some ART cycles

• Enhances egg quality and reproductive hormone balance in research settings

Dosage Guidelines (Research Use)

• Natural Cycles / Follicle Development: 0.3–2 mg SC daily during the follicular phase (7–14 days), adjusting based on response

• Ovulation Induction / ART Protocols: 1–3 mg SC single injection, typically 36 hours before ovulation or egg retrieval

• Body Weight–Based Dose: 6.4–12.8 µg per kg body weight

• Monitoring: Hormone levels (LH, FSH, estradiol, testosterone) should be regularly checked to adjust dosing

Important Notes

• Individual responses may vary; start at the lower end of dosing ranges and titrate as needed

• Designed for laboratory research use only

• Not intended for human or animal consumption or medical use

Useful Information

• Class: Hypothalamic regulatory peptide / GnRH stimulator

• Category: Endocrine & Reproductive Peptides

• Primary Research Focus: Follicular development, ovulation induction, LH & FSH modulation