Tesamorelin Ipamorelin

Description

The Tesamorelin / Ipamorelin Blend is a combination of two complementary peptides designed to maximize the body’s natural growth hormone (GH) output:

• Tesamorelin: A 44–amino acid GHRH analogue that stimulates the pituitary gland to release GH in a physiologic, pulsatile manner, improving IGF-1 levels, lipolysis, and tissue repair.

• Ipamorelin: A selective GHRP that binds to the ghrelin (GHSR-1a) receptor, enhancing GH release without significantly affecting cortisol or prolactin, leading to a “clean” GH pulse.

Mechanism of Action

By combining these two peptides:

1. Dual Pathway Stimulation: Tesamorelin activates the GHRH receptor pathway, while Ipamorelin triggers the ghrelin receptor pathway.

2. Synergistic GH Release: Amplifies both the amplitude and frequency of GH pulses for enhanced metabolic and anabolic effects.

3. Physiologic GH Support: Promotes tissue repair, fat metabolism, and overall body composition improvements without direct GH administration.

Dosage Guidelines (Research Use)

• AM (Morning, Fasted): 1–2 mg Tesamorelin + 333–667 mcg Ipamorelin, 5 days/week before workout

• PM (Evening, Optional): 1–2 mg Tesamorelin + 333–667 mcg Ipamorelin to align with natural GH peak during deep sleep

• Cycle Length: 8–10 weeks with a recommended off-cycle of 4–8 weeks

• Higher Dosage: Should be split into multiple injections for better tolerance

Important Notes

• Carbohydrates and fats may blunt GH release; administer at least 30 minutes before or 2 hours after eating

• Generally well tolerated; mild redness, irritation, or discomfort at the injection site may occur

• Rare side effects may include headache, dizziness, or flushing

Class

Dual GHRH + GHRP Peptide Combination

Research Focus

• Endogenous growth hormone optimization

• Muscle recovery and regeneration

• Fat metabolism and body composition support

• Tissue repair and anti-aging research