Description
Gonadorelin (Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂) is a synthetic decapeptide analogue of natural gonadotropin-releasing hormone (GnRH) secreted by the hypothalamus. It is designed to stimulate the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary, supporting downstream reproductive signaling.
Mechanism of Action
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Binds to GnRH receptors in the anterior pituitary
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Triggers pulsatile secretion of LH and FSH, regulating reproductive hormone production
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Stimulates testosterone and sperm production in males and estrogen and follicular development in females
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Intermittent or pulsatile administration mimics natural hypothalamic signaling, helping reactivate the HPG (hypothalamic–pituitary–gonadal) axis in research models of hormonal suppression or decline
Dosage Guidelines (Research Use)
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Typical Dose: 100–200 mcg administered as a single injection (IV or SC)
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Purpose: Primarily used for diagnostic testing of pituitary function
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Procedure: Blood samples are collected before and after administration to assess LH and FSH response
Important Notes
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Designed for laboratory research use only
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Not intended for human or animal consumption or medical use
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Intermittent dosing is critical; continuous administration may suppress the HPG axis
Useful Information
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Class: Synthetic hypothalamic peptide / GnRH analogue
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Category: Endocrine & Reproductive Peptides
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Primary Research Focus: Pituitary function testing, hormonal regulation, HPG axis studies




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