GHRP-2

GHRP-2 is a synthetic growth hormone-releasing peptide (Ghrelin mimetic) that stimulates endogenous GH secretion. Commonly studied in research for muscle growth, fat metabolism, and appetite regulation, it is often paired with CJC-1295 to enhance physiologic GH pulsatility.

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For laboratory research use only. Not for human or animal use or consumption. Not a drug, food, dietary supplement, or cosmetic. Not approved by the FDA for any medical use.

Description

GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide designed to stimulate the body’s natural growth hormone (GH) secretion by binding to the ghrelin (GHSR-1a) receptor in the pituitary and hypothalamus. This results in pulsatile GH release, increasing both amplitude and frequency of GH pulses, which supports elevated IGF-1, improved fat metabolism, and enhanced muscle recovery.

Mechanism of Action

  • Stimulates endogenous GH secretion through the ghrelin receptor (GHSR-1a)

  • Promotes physiologic pulsatility of GH rather than continuous elevation

  • Supports downstream benefits such as muscle recovery, fat metabolism, and overall anabolic signaling

Dosage Guidelines (Research Use)

  • Typical Dose: 200–500 mcg in the morning before workouts, in a fasted state

  • Frequency: 5 days per week

  • Cycle Length: 12–14 weeks, followed by a recommended off-cycle of 4–8 weeks

  • Higher doses may be split into 2–3 administrations per day

  • Often paired with CJC-1295 for synergistic GH release

Application Notes

  • Used in research protocols focused on muscle growth, appetite stimulation, or recovery from illness

  • Carbohydrates and fats can blunt GH release; best administered 30 minutes before meals or 2 hours after eating

Side Effects (Research Use)

  • Increased hunger (may be beneficial in certain protocols)

  • Water retention

  • Tingling in extremities

  • Gradual dose escalation is recommended to reduce side effects

Useful Information

  • Class: Growth Hormone Releasing Peptide (Ghrelin mimetic)

  • Category: Growth Hormone Peptides

  • Primary Research Focus: GH secretion, fat metabolism, muscle recovery, appetite regulation

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