Description
Selank is a synthetic analogue of Tuftsin, a naturally occurring immunomodulatory tetrapeptide. It is primarily researched for its nootropic, anxiolytic, and neuroprotective properties, making it valuable in studies on cognitive function, emotional regulation, and stress response.
Mechanism of Action
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Modulates GABAergic and serotonergic signaling in the brain
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Influences dopamine and serotonin turnover for mood stabilization
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Enhances brain-derived neurotrophic factor (BDNF) expression, supporting cognitive performance and neuronal health
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Reduces stress-induced inflammatory cytokines such as IL-6 and TNF-α
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Rapid onset (15–30 minutes intranasally) with a half-life of ~2–4 hours
Dosage Guidelines (Research Use)
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Anxiolytic: 400 mcg–1 mg per day, typically divided into two doses (morning and early afternoon)
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Cognitive Enhancement: 200–400 mcg per day, often divided into two doses
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Maximum Dose: 2 mg per week
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Cycle Length: 4–6 weeks, with a 2-week break between cycles to prevent tolerance
Important Notes
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Designed for research purposes only; not for human or animal consumption
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Effects can vary between subjects; dosage should be tailored to study requirements
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Often combined in research protocols with Semax (cognition) or TA-1 (immune modulation)
Useful Information
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Class: Synthetic neuropeptide / anxiolytic heptapeptide
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Primary Research Focus: Cognitive enhancement, mood stabilization, anxiety modulation, and neuroprotection







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