Description
PT-141 (Bremelanotide) is a synthetic peptide analogue of α-melanocyte-stimulating hormone (α-MSH) designed to activate melanocortin receptors (MC3R/MC4R) in the hypothalamus. Unlike peripheral PDE-5 inhibitors, PT-141 works centrally to influence sexual arousal, libido, and related neuroendocrine pathways.
Mechanism of Action
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Activates central melanocortin pathways, enhancing sexual desire and performance
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Modulates dopaminergic signaling, parasympathetic tone, and nitric-oxide–mediated vasodilation
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Influences mood, energy, and central nervous system arousal
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Primarily researched for sexual dysfunction in men and women, including hypoactive sexual desire disorder (HSDD)
Dosage Guidelines (Research Use)
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Men: 1–2 mg subcutaneously per administration; may increase up to 4 mg for research purposes
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Women: 0.5–1 mg subcutaneously per administration
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Frequency: As needed, max once in 24 hours; up to 8 times per month
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Onset of Action: 30–60 minutes post-administration
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Duration: 2–6 hours
Important Notes
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Designed for research purposes only; not for human or animal consumption
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Monitor for blood pressure changes, nausea, flushing, headache, or injection site reactions during experimental studies
Useful Information
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Class: Synthetic melanocortin receptor agonist peptide
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Category: Sexual Function & Neuroendocrine Peptides
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Primary Research Focus: Sexual arousal, libido regulation, CNS melanocortin signaling


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