DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide studied for its role in sleep regulation, stress modulation, and neuroendocrine balance. It is commonly researched for improving sleep onset and sleep quality when administered prior to bedtime.
$39.00
For laboratory research use only. Not for human or animal use or consumption. Not a drug, food, dietary supplement, or cosmetic. Not approved by the FDA for any medical use.
DSIP (Delta Sleep-Inducing Peptide) is an endogenous sleep-regulating and stress-adaptive neuropeptide involved in the modulation of sleep architecture and neuroendocrine function. Originally isolated from the hypothalamus, DSIP has been widely studied for its effects on sleep induction, stress response, pain modulation, and hormonal balance.
DSIP is a naturally occurring nonapeptide with the amino acid sequence:
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
It exerts its effects by modulating GABAergic and NMDA receptor activity, helping stabilize sleep architecture—particularly delta (deep) sleep phases. Additionally, DSIP influences neuroendocrine signaling by regulating the release of melatonin, cortisol, and adrenocorticotropic hormone (ACTH), supporting circadian rhythm balance and stress adaptation.
Standard Dose:
100–200 mcg per day
Timing:
Administer 1–3 hours before bedtime
Typically administered once daily, ideally 30–60 minutes before sleep to maximize sleep-enhancing effects
DSIP may produce paradoxical effects if dosed too high
It is strongly recommended to start at the lowest effective dose and assess tolerance before adjusting
Individual sensitivity to DSIP can vary significantly
Class: Endogenous neuropeptide / sleep-regulating and stress-adaptive peptide
Category: Neuroregulatory Peptides
Primary Research Focus: Sleep induction, stress modulation, neuroendocrine balance
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