CJC-1295 No DAC

Description

CJC-1295 No DAC is a synthetic Growth Hormone–Releasing Hormone (GHRH) analogue engineered to enhance endogenous growth hormone (GH) secretion in a physiologic, pulsatile manner. Unlike DAC-modified versions, the No DAC formulation features a shorter half-life, allowing for precise timing and flexible stacking protocols.

Mechanism of Action

CJC-1295 No DAC is derived from the first 29 amino acids of human GHRH (1-29) and modified for increased stability and bioactivity. It acts directly on pituitary somatotroph cells to stimulate natural GH release without suppressing feedback mechanisms.

Due to its short half-life (approximately 30 minutes), this peptide is ideal for:

• Mimicking natural GH pulses

• Timing GH release around workouts or sleep

• Pairing with GHRPs such as Ipamorelin, GHRP-2, or GHRP-6 for synergistic effects

Dosage Guidelines (Research Use)

Morning Protocol:

• 300–500 mcg, administered before workouts

• Taken in a fasted state

• 5 days per week

Evening Protocol:

• 300–500 mcg, administered at night

• Night-time dosing aligns with the body’s natural GH surge during deep sleep, potentially enhancing muscle recovery, fat metabolism, and tissue repair

Cycle Length

• 8–10 weeks

• Recommended to follow with an extended off-cycle of 4–8 weeks

Stacking Recommendation

• Commonly stacked with Ipamorelin for enhanced GH pulse amplitude and overall effectiveness

Administration Notes

• Carbohydrates and dietary fats may blunt GH release

• Best administered 30 minutes before eating or at least 2 hours after meals

• Fasted conditions are recommended for optimal GH response

Useful Information

• Class: Growth Hormone–Releasing Hormone (GHRH) analogue

• Half-life: ~30 minutes

• Purpose: Supports endogenous GH secretion without desensitization

Important Notes

• Dosage units may be adjusted slightly for practical administration

• Minor variations in dosage are not expected to significantly impact research outcomes