Description
Semax is a synthetic analogue of the adrenocorticotropic hormone (ACTH 4-10) fragment, designed for research into cognitive and neuroprotective effects. It is primarily studied for its ability to enhance memory, learning, focus, and resilience to neural stress.
Mechanism of Action
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Modulates Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) pathways
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Supports dopamine and serotonin balance to improve mood and focus
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Reduces oxidative and ischemic stress in neural tissues
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Promotes neuroplasticity and neuronal survival without affecting cortisol production
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Intranasal administration allows rapid transport across the blood-brain barrier (~30 minutes onset)
Dosage Guidelines (Research Use)
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Cognitive Enhancement: 500 mcg–1 mg per day, often divided into two doses
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Treatment of Ischemic Stroke (research models): 1 mg four times daily for up to 10 days
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Administration: Typically intranasal to ensure central nervous system bioavailability
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Cycle Length: Tailored to study protocol; assess tolerance before increasing dosage
Important Notes
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Designed for research purposes only; not for human or animal consumption
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Dosage frequency and size should be adjusted per experimental requirements
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Effects can vary depending on the subject and protocol
Useful Information
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Class: Synthetic neuropeptide / cognitive & neuroprotective modulator
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Primary Research Focus: Cognitive enhancement, memory consolidation, neuroprotection, anxiety relief







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