PT-141

PT-141, also known as Bremelanotide, is a synthetic melanocortin receptor agonist (MC3R/MC4R) peptide. It is studied for sexual arousal and libido modulation, making it valuable for research on sexual function and hypothalamic signaling pathways.

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For laboratory research use only. Not for human or animal use or consumption. Not a drug, food, dietary supplement, or cosmetic. Not approved by the FDA for any medical use.

Description

PT-141 (Bremelanotide) is a synthetic peptide analogue of α-melanocyte-stimulating hormone (α-MSH) designed to activate melanocortin receptors (MC3R/MC4R) in the hypothalamus. Unlike peripheral PDE-5 inhibitors, PT-141 works centrally to influence sexual arousal, libido, and related neuroendocrine pathways.

Mechanism of Action

  • Activates central melanocortin pathways, enhancing sexual desire and performance

  • Modulates dopaminergic signaling, parasympathetic tone, and nitric-oxide–mediated vasodilation

  • Influences mood, energy, and central nervous system arousal

  • Primarily researched for sexual dysfunction in men and women, including hypoactive sexual desire disorder (HSDD)

Dosage Guidelines (Research Use)

  • Men: 1–2 mg subcutaneously per administration; may increase up to 4 mg for research purposes

  • Women: 0.5–1 mg subcutaneously per administration

  • Frequency: As needed, max once in 24 hours; up to 8 times per month

  • Onset of Action: 30–60 minutes post-administration

  • Duration: 2–6 hours

Important Notes

  • Designed for research purposes only; not for human or animal consumption

  • Monitor for blood pressure changes, nausea, flushing, headache, or injection site reactions during experimental studies

Useful Information

  • Class: Synthetic melanocortin receptor agonist peptide

  • Category: Sexual Function & Neuroendocrine Peptides

  • Primary Research Focus: Sexual arousal, libido regulation, CNS melanocortin signaling

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