IGF-1 LR3 (Receptor Grade)

IGF-1 LR3 Receptor Grade is a modified form of Insulin-Like Growth Factor-1 engineered for enhanced stability and biological activity. Commonly used in research to support cellular growth, tissue repair, and regeneration, it can be paired with Ipamorelin or NAD+ for synergistic effects.

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For laboratory research use only. Not for human or animal use or consumption. Not a drug, food, dietary supplement, or cosmetic. Not approved by the FDA for any medical use.

Description

IGF-1 LR3 (Long Arg3 Insulin-like Growth Factor-1) is a recombinant peptide analogue of human IGF-1 designed for enhanced stability, extended half-life, and increased bioavailability. Modifications including arginine substitution at position 3 and removal of the N-terminal glutamic acid reduce binding to IGF-binding proteins (IGFBPs), allowing a half-life of 20–30 hours compared to 20–30 minutes for native IGF-1.

Mechanism of Action

  • Acts downstream of Growth Hormone (GH) to promote cellular growth, differentiation, and repair

  • Stimulates muscle, cartilage, and connective tissue regeneration

  • Enhances tissue remodeling, cellular repair, and recovery

  • When stacked with Ipamorelin, can amplify GH-mediated effects

  • Research shows NAD+ co-administration may increase energy and exercise performance

Dosage Guidelines (Research Use)

  • Typical Dose: 50–100 mcg administered in the morning, fasted, before workouts

  • Cycle Length: 10–20 consecutive days, followed by an off-cycle of 4–8 weeks

  • Carbohydrates and fats may blunt GH-related effects; best administered 30 minutes before meals or 2 hours after eating

Side Effects (Research Use)

  • Increased hunger (can be beneficial depending on protocol)

  • Water retention

  • Tingling in extremities

  • Gradual dose escalation is recommended to minimize side effects

Useful Information

  • Class: Recombinant Insulin-like Growth Factor-1 analogue

  • Category: Growth Hormone Peptides

  • Primary Research Focus: Cellular growth, tissue repair, regeneration, and recovery

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